What Every Man Must Know About Prostate Cancer and Prostate treatment

Man with Prostate CancerA Malignant tumor that often starts in the outer part of the prostrate is called the Prostate cancer. This may spread to the inner parts of the prostate as the tumor grows. The prostate cancer treatment available for this disease includes watchful waiting, radiation, hormonal therapy, brachytherapy and prostate surgery .

The risk of Prostate Cancer increases with age. Most men diagnosed of the disease are often older than 50 years. African-American men have been proven to have a higher risk of developing this cancer more than other races. Also a family with a history of Prostate cancer often increases the risk for the members of the family. Bout 10% of the disease run in families but till date no good reason has been given for this. Environmental factors like high intake of dietary fat, seems to increase the risk of the disease.

The disease takes time to develop, usually takes between two to four years to double its size. This slow growth usually leads to a long in detection while its building up. Just like every cancer whose process is well known as the growth of abnormal cells until it gets out of control. In this case the abnormal cells of the prostate gland keeps growing until they get out of control.

The best possible ways to prevent the spread of the disease are early diagnosis and prostate treatment . There are so many ways most men can treat and prevent it before prostate treatment is needed, which are by changing unhealthy habits including excessive smoking and drinking of alcohol, taking adequate calcium and vitamin D, then exercising regularly.

Read more: – What Every Man Must Know About Prostate Cancer and Prostate Treatment

Under Creative Commons License: Attribution

Gene Test May Cut Need For Prostate Cancer Surgery

gene_testingA genetic pattern could predict how aggressive prostate cancer is, potentially saving many men with less threatening tumors from undergoing unnecessary and life changing surgery, scientists said on Wednesday.

Prostate tumors can range from relatively harmless ones that grow very slowly and are unlikely ever to cause a problem, to ones that are far more aggressive and need swift treatment. At present doctors have few effective tools to differentiate between varying types.

Details of the Study:

British researchers found that men with the highest levels of “cell cycle progression” (CCP) genes — ones that encourage cells to grow — were three times more likely than those with the lowest levels to have a fatal form of prostate cancer.

The study, published in the Lancet Oncology journal, also found that in patients who had already had surgery to remove their prostate, those with the highest CCP levels were 70 percent more likely to have a recurrence of the disease.

“Our findings have great potential,” said Jack Cuzick, a cancer specialist based at Queen Mary, University of London.

“CCP genes are expressed at higher levels in actively growing cells, so we could be indirectly measuring the growth rate and inherent aggressiveness of the tumor through a test.”

Myriad Genetics in the United States, has developed a test called Prolaris which measures CCP levels and Cuzick said that if further trials confirm his results, doctors could be using it in prostate cancer patients within a year.

Prostate cancer killed an estimated 258,000 men around the world in 2008 and is the second most common cause of cancer death in men in the United States. In Britain, about 35,000 men are diagnosed with it and some 10,000 die from the disease each year.

Being able to distinguish between aggressive tumors and slow-growing ones could spare many men unnecessary treatment and side effects like impotence and incontinence.

The study looked at 703 men with prostate cancer — 366 men in America who had undergone surgery to remove the prostate, and 337 men in Britain with cancer that was confined to the prostate and were judged to not need immediate treatment.

The untreated group were given what is called a “watch and wait” option, which allows doctors to try to avoid treating men whose prostate cancer will not cause them significant problems. Tissue samples from the prostate were either taken during surgery or from the biopsy used to diagnose the disease.

Researchers then tested each sample for levels of 31 different genes involved in CCP and were able to show that specific combination of these gene levels can identify men at high or low risk of the disease spreading beyond the prostate and those most likely to die.

Cuzick said previous studies had already shown that CCP levels can predict survival for breast, brain and lung cancers.

Helen Rippon, head of research management, at the British Prostate Cancer Charity, said in a statement the technology must be “comprehensively trialed in large numbers of men before it can be introduced into routine clinical practice.”

SOURCE: – Gene test may cut need for prostate cancer surgery

FUS: Protein that may destroy Prostate Cancer

FUSIn what can be termed as an important step in the battle against prostate cancer [abnormal cells that divide without control, which can invade nearby tissues or spread through the bloodstream and lymphatic system to other parts of the body. ] , scientists have discovered a key protein which not only suppresses the growth of the malignant cells, but also triggers a pathway that leads to their suicide.

Details of the Study:

According to experts, the identification of the protein known as FUS (Fused in Ewing’s Sarcoma) could be used to treat and even cure the lethal disease in men.

Prostate cancer [Prostate cancer is a disease in which the cells of the prostate become abnormal. They start to grow uncontrollably, forming tumors. A tumor is a mass or lump of tissue made of abnormal cells. Tumors may be malignant or benign. A malignant tumor can spread to other parts of the body. Malignant tumors are cancerous. Benign tumors cannot spread to other parts of the body.] is the second leading cause of cancer death in men today.

The disease is typically slow-growing, but can at times take an aggressive form and spread rapidly to the bone and other organs which can turn fatal.

FUS protein inhibits growth of tumors

The research team from the Imperial College London studying the effect of male hormones [chemical substances created by the body that control numerous body functions.] on prostate cancer cells found that FUS inhibits the growth of tumors.

They noted that patients whose prostate cancer cells had high levels of FUS had less aggressive tumours. In addition, they were inclined to survive for a longer period.

Researchers theorize that FUS levels could be used as a marker to predict how aggressive the disease is likely to be.

Dr Charlotte Bevan, senior author of the study, from the Department of Surgery and Cancer at Imperial College London, stated, “At the moment, there’s no way to say whether a prostate tumour will kill you or be fairly harmless.

“Current hormonal therapies only work for a limited time, and chemotherapy is often ineffective against prostate cancer, so there’s a real need for new treatments.”

“These findings suggest that FUS might be able to suppress tumour growth and stop it from spreading to other parts of the body where it can be deadly. It’s early stages yet but if further studies confirm these findings, then FUS might be a promising target for future therapies.”

A laboratory study

Prostate cancer is aggravated by male hormones that divide the cancer cells which multiply and spread.

Since, high hormone levels cause the cells to produce less of the protein FUS, the scientists conducted an experiment by adding more of the protein in the cancer cells in a dish.

It was noted that when the cells were producing more FUS, there was a significant reduction in the growth of prostate cancer cells.

Greg Brooke, from the Department of Surgery and Cancer at Imperial College London, said, “Our study suggests that FUS is a crucial link that connects male hormones with cell division. The next step is to investigate whether FUS could be a useful test of how aggressive prostate cancer is.

“Then we might look for ways to boost FUS levels in patients to see if that would slow tumour growth or improve response to hormone therapy.

“If FUS really is a tumour suppressor, it might also be involved in other cancers, such as breast cancer, which has significant similarities with prostate cancer.”

The study has been sponsored by Prostate Action, the Medical Research Council, The Prostate Cancer Charity and Imperial College and the findings are to be published in the ‘Cancer Research’ journal.

SOURCE: – Scientist discover protein that suppresses prostate cancer

Newest Experiment May Help Guide Prostate Cancer Treatment

Laboratory Technician Examining MouseThe latest experiment will someday benefit the doctors to guide them of the most difficult problems in cancer therapy: finding which prostate cancer patients needs full treatment.

Currently, once prostate cancer is diagnosed, doctors have no reliable way to know which cases are life-threatening. Most are not. So doctors have a difficult time determining whether they should monitor the cancers to see if they progress or recommend immediate treatment, such as surgery or radiation. Both treatments can cause problems, such as incontinence and impotence.

The dilemma results in overtreatment, such that about 48 men are treated for every life saved, says Dr. Ronald DePinho of the Dana-Farber Cancer Center in Boston.

But DePinho and colleagues have created a test they say might help doctors identify dangerous tumors more accurately than is possible now. In results published online Wednesday by the journal Nature, the scientists showed an improvement in accuracy to 91 percent from 84 percent.

When applied to prostate cancer samples, the gene test indicates “how this particular cancer is wired to behave,” DePinho said.

Details of the study on how this new test will help Prostate Cancer treatment

Drawing on research in mice, DePinho and colleagues identified four genes whose combined activity within cancers appears to drive prostate tumors toward being lethal. The genes are involved in processes like growth and ability to invade other tissues.

Then the researchers tested whether the combined activity of those genes also predicted cancer outcome in men, with a series of tests in human tumor samples.

In the largest test, they looked at 405 tumor specimens from men who’d been diagnosed between 1983 and 2004. Thirty-eight cases turned out to be lethal. Researchers looked for the chemical signatures of gene activity in the samples and tested how accurately that could classify tumors as lethal or not.

By itself, the gene test performed about as well as a combination of current indicators: age at diagnosis, indications of tumor spread and a “Gleason score” that assesses the appearance of tumor cells under a microscope. That standard approach was accurate 84 percent of the time in the study.

But accuracy rose to 91 percent when researchers combined that approach with the gene test. The combination “robustly predicted which men were going to die of the disease,” DePinho said.

The rights to develop the test have been licensed to a company that DePinho co-founded and in which he holds a financial interest.

Experts not connected with the study praised the work but said more research on the gene test is needed.

“It’s early still, but it’s pretty exciting,” said Dr. Eric Klein of the Cleveland Clinic. “This is a step in the right direction, without question.”

Dr. Angelo De Marzo, a professor of pathology, oncology and urology at the Johns Hopkins School of Medicine in Baltimore, called it “extremely interesting, promising, amazing work.”

It will take more research to see whether the gene test really could help doctors make treatment recommendations with more confidence than they can now, and in what situations, he said. The test might prove useful when prostate cancer is diagnosed from biopsy samples, or in deciding on further treatment after a man’s prostate has been removed, he said.

De Marzo noted that some prostate cancer researchers are meeting this weekend, and “I have a feeling there’s going to be a ton of buzz about this at that meeting. I think people are going to be very excited.”


Yahoo News! – New test may help guide prostate cancer treatment

Higher Intake of Fish Means Low Risk of Prostate Cancer

FishResearch shows that men with a higher intake of fish had a slower spread of prostate cancer and a lower risk of death compared to those who didn’t eat as much fish. With over 215,000 new cases of prostate cancer and more than 32,000 deaths in 2010 in the U.S. alone, that’s a reason to choose sushi over barbecue for lunch.

Details of the study why fish helps lessen the risk of Prostate Cancer

Fish are high in a fat that is essential to have in your diet: omega-3s, a healthy, polyunsaturated fat. It’s needed for your body to carry out a variety of different processes. Lately, it has gained popularity because of its anti-inflammatory effect, which is important for everyone, as inflammation in the body can be caused by or be a risk factor for disease.

If you have difficulty making changes to your diet without a plan of attack, you could follow the Okinawa or Mediterranean diets, which are both high in fish and low in meat. By following the Mediterranean diet, you’d also be helping your heart and possibly preventing diabetes or by living like an Okinawan (a Japanese island who have the largest population of 100+ aged people), you might follow their trend of having long, healthy lives.

SOURCE: – Fish Slows Spread of Prostate Cancer

Healthy Ways in Treating Prostate Cancer Problems

Men's FitnessAccording to a traditional medical practitioner, Dr Olusegun Fahuwa, an enlarged prostate is a common occurrence as men reach their 60s. The official medical term is benign prostatic hyperplasia (BPH). He said: “As the prostate enlarges, it interferes with urination. Common symptoms include difficulty in urinating, going to the bathroom frequently, weak stream and trouble in emptying your bladder. A natural treatment strategy involves lifestyle recommendations and certain natural supplements. You should consult with an experienced health care provider to design a regimen, and always tell your doctor about any supplements you want to use.”

Details of the Study:

He described the prostate as a small male gland located between the bowel and the bladder that can almost double in size during puberty due to certain changes in the male hormone testosterone. Years of research has still not been able to find out the exact purpose of the prostate gland, but it is known that fluid from the prostate mixes with sperm during ejaculation.

The trado medical doctor said: “Many middle aged men will face problems with an enlarged prostate gland. Too often, it is because men are reticent about talking about prostrate problems. Early detection could mean a quick cure so it would be wise to go for a check-up as soon as any kind of discomfort is felt in the area. It could make the difference between life and death. Although the growth of prostate is usually benign and known as Benign Prostatic Hyperplasia (BPH), there is always a risk of it becoming malignant.

Treating Prostate Cancer

Giving tips on how to manage symptoms through diets, the producer of seto (cassia alata) an herbal preparation for treatment of the condition said: “The person should avoid or limit alcohol and caffeine. They irritate the bladder and will only contribute to urinary difficulties.

“Eat 20 to 35 grammes of fibre daily to encourage regularity. Constipation worsens BPH symptoms. High-fibre foods include whole grains, fruits, vegetables and beans. Take a fibre supplement if you find it difficult to consume adequate fibre through your diet. Limit your intake of saturated fat, which is abundant in animal products. Choose low-fat dairy and non-meat protein sources such as beans, whole grains and soy.

“According to an alternative medicine expert, Dr. Andrew Weil, Asian men have a much lower incidence of BPH, and researchers believe it is linked to soy consumption. Also the University of Maryland Medical Centre, all of the following supplements improved various symptoms of BPH in clinical studies. You do not need to take every supplement listed, as some offer the same results. This is an area of alternative medicine where talking with a professional is helpful. He can offer guidance on a supplement regimen”.

A source revealed that Beta-Sitosterol, naturally found in plants, improved flow and reduced the amount of urine remaining in the bladder. It did not reduce prostate size. Take 60 to 130 mg daily. Pumpkin seeds are a rich natural source of this compound and have a long history of use in promoting prostate health.

Saw palmetto works in a similar fashion as prescription medications that keep testosterone from changing into a chemical that fuels prostate growth. Suggested dosage is 320 mg daily. It should be noted that while many studies found benefit, some did not.

Pygeum is a traditional treatment for urinary difficulties, and studies found it was especially good at reducing the frequency of night-time urination and encouraged better urine flow. Take 75 to 200 mg daily.

And for those nursing fear of prostate cancer, he said to keep cancer at bay, a good diet to follow would be one that includes nuts, vegetables such as cabbage, broccoli and kale, fruits like apples, grapefruit and papaya (pawpaw), oatmeal, fish and fish oil and seeds like flax, pumpkin, sunflower and sesame.

“Foods best avoided are red meats, alcohol, refined sugar, hydrogenated fats and soft drinks. Salmon helps fight inflammation. Research has found that men who ate it regularly had a 300 per cent lower chance of prostate enlargement. One nature cure recommends pureeing a few aloe vera leaves, combining it with a cup of honey and cooking it for 15 minutes. It is then mixed with three tablespoons of brandy and a teaspoonful taken every eight hours for a month”.

SOURCE: – How to treat prostrate problems

Scientists At Work in Making Prostate Cancer Treatment Safer

Scientist at WorkMen usually survive prostate cancer (about 95 per cent are still alive after five years), but many suffer side effects because surgery and radiation can affect surrounding delicate tissue.

The prostate is a walnut-sized gland located just above a man’s rectum. It creates fluid that carries sperm during ejaculation.

Details of the study on how scientist do research for a safer Prostate Cancer treatment

One recent Canadian study is using frequent, high-tech digital imaging to follow changes that can happen day-to-day inside a man’s body. These tiny changes can alter very slightly the radiation target.

Dr. Craig and colleagues recently won a CASARIA award and funding from the Canadian Radiation Oncology Foundation and sanofi-aventis, which allows them to start enrolling patients later this year.

“Very simple and natural changes in patient anatomy can occasionally complicate treatment,” says Dr. Craig. “For example, reduced bladder filling might allow the very sensitive small intestine to slip into the high radiation dose region. Without image-guidance, this would not be known, and the small intestine may receive an unsafe dose. With ART, we can see this, and use this information to adapt the treatment to ensure a safe dose.”

A typical course of radition treatment for prostate cancer patients after surgery is 33 treatment days over six and a half weeks.

Finger length and prostate cancer

Men, have a look at the index finger on your right hand. Is it longer than your ring ringer?

If it is, you have a lower risk of prostate cancer than your buddies who have a longer ring finger.

Researchers in the U.K. studied the hands of 1,524 men with prostate cancer and 3,044 men without prostate cancer. They found men with a longer ring finger were more likely to develop prostate cancer. Finger length could help in selecting men for screening.

SOURCE: – Scientists work to make prostate cancer treatment safer

How Doctors Diagnosed Prostate Cancer

Prostate Cancer patientA biopsy is not usually painful, but you may feel a sharp scratch, even if you are given a local anaesthetic (painkiller) to numb the area.

The more abnormal the cancer cells look compared with healthy prostate cells, the more likely the cancer is to be aggressive and able to spread.

How doctors know how far the cancer has spread

Most of the time, doctors will know whether your cancer has spread by looking at a combination of your PSA level and your biopsy results. If they need more information about your cancer, doctors can use special techniques to look at other parts of your body, including your lymph nodes and your bones. They may use ultrasound scans, X-rays or body scans (computed tomography and magnetic resonance imaging) to check whether cancer is anywhere else in your body.

From the results of your tests, you doctor will be able to tell you:

  • How big your prostate cancer is
  • How likely it is that your prostate cancer has spread to your lymph nodes
  • Whether your prostate cancer has spread to other parts of your body
  • What type of prostate cancer cells you have and how fast they are likely to grow and spread.

How doctors classify your cancer

Doctors use number and letter classification systems to describe how far your cancer has spread. This is called staging. There are several systems, but the most common is called the TNM system. See our explanation of the TNM system to find out what the different classifications mean.

How doctors grade your cancer

Doctors use something called the Gleason score to describe how your cancer looks under a microscope. This is called your cancer grade. A tumour that has a low-grade score is likely to be growing slowly, while one with a high-grade score is more aggressive and likely to spread. If your cancer has been given a grade, read our explanation of the Gleason score to learn more about what it means.


WebMD – Prostate Cancer – How Do Doctor Diagnose Prostate Cancer?

Coffee Intake Relationship with Prostate Cancer

coffeeA new study is suggesting that there is no existing link or any strong evidence between prostate cancer and drinking coffee. This comes after previous studies associating coffee with a host of cancer disorders.

The research was led by Dr. Chang-Hae Park from the National Cancer Center in South Korea. They looked at the results given by 12 studies in the past that compared coffee intake and prostate cancer risk. The researchers say that the study designs were mainly responsible for the discrepancy.

Details of the study why Prostate Cancer and coffee debunked

As claimed by the researchers, of the 12 studies, 8 used case-control studies that had several limitations. When the research team analyzed the data in case-control studies, the same results showed for all, which suggested higher risk for cancer of the prostate with increased coffee intake. Meanwhile, the remaining four did not have the same findings.

The research can be read at the medical journal, BJU International. As noted, it again adds to the confusion of the true association between cancers and coffee.

SOURCE: – Link Between Prostate Cancer and Coffee Debunked

Soya Beans Reduce The Risk of Prostate Cancer

Soya BeansSoya beans may be the key to protection against two of the most dangerous cancers.

Two new university studies show the food can stop the spread of prostate cancer and guard against breast cancer.

Researchers from a Chicago university found that one pill a day of genistein, a nutrient found in soya, appeared to turn on genes that prevent the spread of cancer cells. This may keep them localised and stop the widening of the disease.

Details of the study on how soya beans reduce the risk of Prostate Cancer

Meanwhile a separate study of more than 1,200 women in New York showed that isoflavones – oestrogen-like plant chemicals found in soya beans – can reduce both the risk of getting breast cancer and the size of tumours.

[click to continue…]