Modified Citrus Pectin
A major study out of Columbia University showed benefits of modified citrus pectin (MCP) on cancer cells. Scientists at Columbia University published a paper showing that MCP stops the growth of prostate cancer (CaP) cells in the test tube. Most significantly this effect was seen in both hormone-dependent and hormone-independent forms of the disease.
Dr. Jun Yan and Dr. Aaron Katz tested two versions of MCP, PectaSol and PectaSol-C, both invented by Dr. Isaac Eliaz. In general, the new form of product outperformed the earlier version. The authors looked at apoptosis (the most prevalent form of programmed cell death) as well as at the inhibition of cell growth. A one percent solution of PectaSol-C was toxic to five cell lines. After four days of treatment, the total destruction of cancer cells ranged from 23.0 to 52.2 percent. The authors concluded that PectaSol and PectaSol-C both inhibited cell proliferation and apoptosis in prostate cancer cell lines.
What is MCP?
Modified citrus pectin (MCP), a compound derived from the rind and pith of citrus fruit, is absolutely essential in the treatment of prostate cancer.
Modified citrus pectin can inhibit metastasis by binding to galectin molecules and blocking them. Galectins are overexpressed adhesion and blood vessel-attracting surface molecules that are thought to be involved in the spread of cancer.
MCP and CaP
Early research on prostate cancer showed that oral administration of MCP to rodents resulted in a dramatic reduction in prostate cancer metastasis to the lungs.
A pilot trial using PectaSol MCP at 15 grams a day and a subsequent phase II trial both showed that MCP slows the progression of prostate cancer as evidenced by a reduction in the rate of PSA rise.Â The phase II trial involved men where primary conventional treatment was initially successful, but subsequently their PSA began to climb again, representing cancer recurrence. This time, 70 percent of the trial participants showed a significant reduction in the rise of their PSA climb.
My take on this
As a Naturopathic doctor who specializes in prostate cancer, I find MCP (Pectasol-C) to be invaluable in my practice. Generally it is used for men who are diagnosed with prostate cancer in any stage in conjunction with any treatment. It does not seem to interfere with any other treatments.
How do I use MCP?
- In conjunction with other important nutrients like Vitamin D3
- For men who are undergoing a prostate biopsy for its anti-metastatic effects
- Men who will undergo prostate surgery for its anti-metastatic effects
- Men who have undergone prostate treatment and have a Gleason 7 or higher with a PSA of 10ng/ml or higher and with extra prostatic extension (CaP cells outside of the prostate gland)
- In men with hormone-independent disease.
MCP seems to be safe and tolerable to most.Â The powder form can be mixed with 4 ounces of 100% pomegranate juice for a nice â€œduoâ€ effect. Pomegranate juice has shown to be beneficial for prostate health.
It is important to know that if you have prostate cancer or think you have prostate cancer, you need to be evaluated by an urologist. Just taking natural products, like MCP without proper supervision and surveillance by a physician is irresponsible and possibly life threatening. Of course, your urologist may not know anything about MCP or nutrition in general â€“ that is normally the case.Â However, being monitored to see progression or regression of CaP is essential. You always should have a Naturopathic doctor on board to give you proper supplement guidance. Remember, Integration of medicine, where modern medicine is combined with ancient, holistic medical techniques and optimal nutrition is how you and your family will get Â the best health results.
In Optimal health
Glinskii OV, Huxley VH, Glinsky GV, et al. Mechanical entrapment is insufficient and intercellular adhesion is essential for metastatic cell arrest in distant organs. Neoplasia. 2005 May;7(5):522-7.
Pienta KJ, Naik H, Akhtar A, et al. Inhibition of spontaneous metastasis in a rat prostate cancer model by oral administration of modified citrus pectin. J Natl Cancer Inst. 1995 Mar 1;87(5):348-53.
Guess BW, Scholz MC, Strum SB, Lam RY, Johnson HJ, Jenrich RI. Modified citrus pectin (MCP) increases the prostatespecific antigen doubling time in men with prostate cancer: a phase II pilot study. Prostate Cancer Prostatic Dis. 2003;6(4):301-4.
Huang Z, Liu H. [Expression of galectin-3 in liver metastasis of colon cancer and the inhibitory effect of modified citrus pectin]. Nan Fang Yi Ke Da Xue Xue Bao. 2008;28(8):1358-1361.
Jackson CL, Dreaden TM, Theobald LK, et al. Pectin induces apoptosis in human prostate cancer cells: correlation of apoptotic function with pectin structure. Glycobiology. 2007;17(8):805-819.
Liu H, Huang Z, Yang G, Lu W, Yu N. Inhibitory effect of modified citrus pectin on liver metastases in a mouse colon cancer model. World J. Gastroenterol. 2008;14(48):7386-7391.
Yan J, Katz AE. PectaSol-C Modified Citrus Pectin Induces Apoptosis and Inhibition of Proliferation in Human and Mouse Androgen-Dependent and -Independent Prostate Cancer Cells. Integr Cancer Ther. 2010. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/20462856 [Accessed May 14, 2010].