CaPLESS & Prostate Cancer

A Thriver After Prostate Cancer

Chris is one of the most amazing CaPLESS Thrivers I know. When I first met him about six years ago, he was 47 years olds with a PSA of 27.0. After biopsy, we discovered he had Gleason 9 prostate cancer all over his prostate.

But that’s not all.

Three months after his prostatectomy, his PSA was 20.0. [there is no error where the decimal point is placed] This could have been a gloom and doom situation but Chris made a 180 degree change to his lifestyle and today he is a Thriver!

He does Cross Fit at CF 140 in Atlanta with his amazing trainer David Argel who I had the pleasure of speaking with recently.     Check out this video of Chris doing Cross Fit. If you are not inspired by Chris and ready to get going, nothing will. Thrive, Don’t Only Surivive!

 

Does a Keto Diet Work for Prostate Cancer?

[ image from Natural Living Ideas]

 

All cells of the human body require energy in the form of Adenosine TriPhosphate (ATP) to support life. If you remember way back in high school, you learned that the mitochondria are the “powerhouse” of the cell as it produces the majority of ATP. When the mitochondria are impaired, its malfunction is implicated in the majority of today’s most concerning chronic and degenerative diseases including obesity, cardiovascular disease, cancer, and diabetes, to name a few.

What is the ketogenic, mitochondria and health connection?

Initially, ketogenic diets were used to treat seizures, but recent research indicates that benefits related to the management of epilepsy, weight loss, metabolic syndrome, and type 2 diabetes can be achieved with an approach that is less restrictive in carbohydrate and protein, and therefore more satisfying, sustainable, and feasible for the general population.

What is a Ketogenic Diet?

Ketogenic diets (KDs) are diets that mimic the metabolic state of fasting by inducing a physiological rise in the two main circulating ketones, acetoacetate and beta-hydroxybutyrate (BHB).

This is a simple version of how the ketogenic diet works.

When your cells are deprived of glucose (sugar) as its primary source of energy, your body kicks in the next gear and utilizes fat for fuel in the form of ketones.

One can create ketones from either fasting for a prolonged period, anywhere from 16 hours a day or for several days, or from eating a high-fat diet, which is what a ketogenic diet is.

To be clear, a ketogenic diet (KD) is not a high protein diet like paleo form of eating. It is a fat diet where lard is in, along with other oils, coconut being a favorite, butter, avocados, etc.

The Ketogenic Diet and Cancer Connection

KDs target the Warburg effect, a biochemical phenomenon in which cancer cells predominantly utilize glycolysis (burns sugar) instead of oxidative phosphorylation (OXPHOS) to produce ATP (energy). Don’t get caught up on what OXPHOS means or how it works for now but know that healthy cells work by using this metabolic pathway.

Thus, the rationale in providing a fat-rich, low-carbohydrate diet in cancer therapy is to reduce circulating glucose levels and induce ketosis such that cancer cells are starved of energy while normal cells adapt their metabolism to use ketone bodies and survive.

To date, the most reliable evidence for KD in suppressing tumors has been reported for glioblastoma (a type of brain cancer).

The proposed mechanism for how the Ketogenic diet works for cancer is like this.

Cancer cells have dysfunctional mitochondria and lack specific enzymes necessary for effective ketone body utilization. In other words, malignant cells can’t use ketones for energy but healthy cells can.

Free fatty acids and ketone bodies are considered to become a significant fuel for normal tissues of cancer patients as a consequence of developing insulin resistance. Additionally, ketone bodies have been shown to suppress protein catabolism during starvation (more on this further down.)

Ketogenic Diet and Prostate Cancer: Yes or No?

There have been no studies on a KD and prostate cancer.

However, there is a small pilot, non-randomized study going as we speak looking and this dietary approach among a sample of 12 overweight or obese prostate cancer patients on active surveillance. The result will not be available until the Spring of 2021.

Besides there being no studies, should a man with prostate cancer implement a KD?

Yes and no.

Here’s the deal;

In one mice study looking at the effects of a no carbs keto diet (NCKD), 10% carb diet and a 20% carb diet on prostate cancer showed is no difference between low-carbohydrate and no-carbohydrate diets regarding prostate cancer growth and progression.

The other important point is that most types of prostate malignancies are not glycolytic cancers like glioblastoma’s thus the Warburg effect does not apply. Clinically this is relevant, as these cancers will not appear on fluorodeoxyglucose (FGD) PET scans. However, in the late stage, more aggressive metastatic prostate cancer there may be more of a Warburg effect and have a high glucose uptake.

In other words, low-grade prostate cancer and high-grade metastatic prostate are two entirely different animals in how they behave.

Dr. Geo’s Take On the Ketogenic Diet and Prostate Cancer

A low carbohydrate diet, which is what promote in the CaPLESS Method, of about 50 to 60g of carbs total (not sugar, carbohydrates) a day is still, eliminating refined; processed carbs is still essential for early-stage prostate cancer without metastasis or positive FDG PET scan.

The reason why a low carb diet is vital to beat non-metastatic prostate cancer is not that of glucose uptake of cancer cells, but the problems excess insulin and insulin resistance cause in promoting disease. In fact, there are data to suggest that patients with early-onset, type one diabetes mellitus (not type two) whose pancreas is no longer able to produce insulin are significantly less likely to develop prostate cancer, independent of diet changes.

If a huge guy is diagnosed with prostate cancer, then his high basal metabolic index (BMI) increases the risk of not only getting prostate cancer but dying from it.

It is a good idea for an overweight person with prostate cancer to restrict carbs more than most as low carb diets, and a KD has shown to help with weight loss.

Intermittent fasting of 12 to 16 hours a day is an excellent practice for prostate cancer and overall longevity.

Lastly, ketones from fasting would be contraindicated in cancer patients with rapid weight loss (cachexia) unless higher fat intake is consumed to avoid further weight loss. Additionally, ketone bodies have been shown to suppress protein catabolism during starvation – meaning that one can maintain muscle from breaking down while utilizing ketones for energy.

Adding medium-chain triglyceride (MCT) to KD in a study to five severely cachectic cancer patients for one week induced a significant weight gain of 2 kg and improved their performance status.

The bottom line is this: A low-carbohydrate, non-ketogenic diet is recommended for prostate cancer with few exceptions: one if the patient has a high BMI, or if prostate cancer is more advanced and shows on glucose dependant PET scan.

My Favorite Books on the Warburg Effect, Metabolic Approach, Ketogenic Diet on Cancer

Three Recent Blog Post

The Real Cause of Prostatitis and How to Treat it Naturally

Prostate Cancer: Late night eating increases the risk.

How to Prevent a Heart Attack: Part one

 

CaPLESS EVENTS

The CaPLESS Retreat is coming in September to help prostate cancer (CaP) thrivers live their best life by implementing science-based lifestyle practices. Prostate cancer is an opportunity to live healthier than before your diagnosis. Learn how. There is limited space.

Prostate Cancer: Late Night Eating Increases the Risk

I spend much of my clinical time talking to patients about nutrition and helping them choose what to eat.

As always, I challenge my knowledge to do better for my patients and my family.

As of late, the conversation on eating has shifted a bit not only on the what to eat but also on when to eat.

Here’s the deal; it turns out the earlier your meals, the less likely you will get prostate cancer or breast cancer based on this new study.

Study Details:

  1. Case-controlled based study conducted in 12 Spanish regions in 2008–2013
  2. 1,738 breast and 1,112 prostate incident cancer cases
  3. People working night-shift (which increases prostate and breast cancer risk) were excluded from the study to control for the possibility of night shift work being the cause of cancer and not nighttime eating

CONCLUSION: Those who ate their last meal of the day before 9 p.m. was found to have a 20 percent lower risk of breast and prostate cancers than compared to those who ate after 10 p.m. or went to bed right after dinner, those

Dr. Geo’s take on Late Night Eating for Cancer

This is not the first study suggesting against late night eating for disease prevention.

In a group of over four hundred overweight participants, late eaters had a more difficult time losing weight compared to early eaters despite having similar age, appetite, hormones values, food intake, sleep duration, etc.

Another study observed that those who ate late at night had 55% higher risk of heart disease compared to the early eater.

Interestingly, in Traditional Chinese Medicine (TCM), which I trained in as well, digestion is a yang activity, and nighttime is yin – doing a yang activity doing yin time contributes to disease in TCM.

The ill effects of eating late are not necessarily what I want to hear as nighttime eating can feel soooo gooood.

Here are some holistic but realistic tips:

  • Know that doing the right things, i.e., exercising, last meal early, taking good supplements it’s not supposed to be always fun, but its essential to do if the goal is to live longer and function optimally. Some pain, psychological or physical is OK.

 

  • Life happens. Sometimes is a toss-up between coming home late from work and not eating or having a meal with your family even though it’s 10 pm. I would opt with eating with my family, eat light and not eat again for 12 to 16 hours later (intermittent fasting). Implement this same advice with late-night dinner meetings and holidays.

 

  • Eat less protein at night and more carbs. Yeah, I know this is tough to do at a steakhouse and anti-paleo but here’s the story; protein gives you energy, carbs have a calming effect by secreting more serotonin, a precursor to the sleep hormone melatonin. Now, if you eat too many carbs, especially processed carbs (i.e. bread, pasta, etc.) you will have a carb hangover the next morning – that awful, dragging feeling as if you downed ten shots of tequila. Eat small portions of whole carbs like sweet potato, rice, etc.

 

  • Get to bed early. The longer you’re up, the more you will want to eat.

 

  • Take the dietary supplement, 5-hydroxytryptophan (5-HTP) if you crave food at night. Tryptophan is an amino acid precursor to serotonin, and it has been my experience it reduces cravings at night. There might be some sleep benefit there as well.

You only get one shot at living your best life. You don’t always have to like doing the right things – do them anyway. Don’t eat after 8 pm, most days of the week. Change is good. Purposeful, smart pain is good too. Enjoy the benefits. Trust the process. Also, often what is good for prostate (and breast cancer) prevention is also good after the diagnosis of these diseases as well.

Three Recent Blog Post

How to Prevent a Heart Attack: Part one

Prostate Cancer: The Truth on Dietary Supplements During Radiation Therapy

It’s time to Exercise. No Excuses.

 

CaPLESS EVENTS

The CaPLESS Retreat is coming in September to help prostate cancer (CaP) thrivers live their best life by implementing science-based lifestyle practices. I to connect with you there. There is limited space.

Prostate Cancer: The Truth On Dietary Supplements During Radiation Therapy

[image from Science Life, University of Chicago Medicine]

 

One of the challenges I have when working with a patient undergoing radiation for prostate cancer is whether or not to have them take dietary supplements.

You see, radiation works by producing oxidative stress (free radicals) in an effort to kill cancerous cells. So, in theory, if you take, say, 500mg of vitamin C, an antioxidant, that would protect the cancerous cells from radiation treatment.

The premise that antioxidants from dietary supplements protect cancerous cells from radiation therapy is a lousy theory.

Allow me to explain…

How Radiation Treatment Works for Prostate Cancer

The ultimate goal from radiation treatment (RT) either by external beam RT or brachytherapy (seeds) for prostate cancer (CaP) is to cause irreparable damage to the DNA of the cell and thereby to cause cell death.

DNA damage is caused both by the direct and indirect effect of RT. About two-thirds is an indirect effect produced from the ionizing radiation creating active oxygen radicals (free radicals) such as hydroxyl radicals that may increase oxidative stress, not only to cancer cells but the whole body of the patient.

The oxidative stress is the primary cause for most side effects that include secondary cancers, urinary and fecal problems experienced by prostate cancer patients during and after radiotherapy.

If prohibition of using antioxidant from dietary supplements during  RT  by radiation oncologist a theory, then we can also theorize that antioxidants help protect healthy, non-cancer cells from the damage of  RT. No?

Patients are going to use dietary supplements during and after RT for cancer in hopes to improve their outcome. About 81% of RT cancer patients do so without ever telling their physician.

Can Antioxidants Help or Hurt During  Radiation Therapy

On this paper  Dr.Kenneth Conklin, MD, Ph.D. from the University of California, Los Angeles (UCLA) Medical Center, questions the theoretical basis for the argument against concurrent anti-oxidant usage.

Dr. Conklin acknowledges that radiation does indeed kill cells by generating high levels of free radicals, but this does not necessarily preclude the use of antioxidants as adjuvant dietary supplements during treatment. Conklin points out that radiotherapy is most useful in well-oxygenated tissues.

Antioxidants, as a class, improve blood flow and therefore promote the normal oxygenation of tissues, thereby rendering tumors more—not less—susceptible to radiation.

Numerous studies have shown that vitamin E and selenium protect against radiation-induced cancers.

A precise combination of antioxidants can help decrease damage expected from radiotherapy, including the formation of other cancer, especially in high-dose radiation since RT reduces tissue antioxidants.

In laboratory animals, for example, radiation exposure has demonstrated to reduce cellular vitamin E levels.

In other studies, radiation has shown to reduce bone marrow vitamin C and E levels, and in clinical studies in breast cancer patients, vitamin A, C, and E and selenium levels were found to be reduced during cancer radiotherapy.

Dr. Charles Simone, a radiation oncologist, surveyed the peer-reviewed literature on the use of supplements and antioxidants administered with chemotherapy and radiation therapy from 1996 through 2003.

He identified 280 peer-reviewed articles on this topic, of which 50 were clinical trials involving a total of nearly 9000 patients. Dr.Simone concluded that these studies have “consistently shown that non-prescription antioxidants and other nutrients do not interfere with therapeutic modalities for cancer.”

In fact, according to Dr. Simone, antioxidants enhanced the effectiveness of standard therapeutic modalities while diminishing adverse effects and protecting healthy tissue.

In 15 of the studies reviewed by Dr. Simone and his group, close to 4000 patients who took nonprescription supplemental antioxidants not only did not fare worse from dietary supplement intake but improved survival.

Major Study on Antioxidants during Radiation Therapy for Cancer

There is one major study I suspect most physicians extrapolate from to conclude against antioxidant use during RT.

Bairati and colleagues set out to determine whether supplementation with antioxidants (alpha-tocopherol (vitamin E) and/or beta-carotene) significantly mitigated adverse effects of radiation in 540 patients undergoing treatment for head and neck cancer.

Superficially reading this paper you’d think antioxidants promote worse outcomes when taken during RT since patients receiving supplementation in addition to radiation had a higher rate of second primaries and local recurrences while receiving the vitamins.

A closer reading of the Bairati study, in fact, shows that by the completion of the study, eight years after the start of radiotherapy, there were fewer second primaries or recurrences in the supplementation group compared with those receiving a placebo (113 vs. 119 participants, respectively).

Also, there was a 62% reduction in severe adverse effects to the larynx and other anatomical sites in those who were randomized to receive both antioxidants.

These mitigating facts were generally downplayed or ignored in a storm of negative publicity that was generated around the Bairati trial, after publication on the Journal of Clinical Oncology.

A 2006 study further analyses of the group studied by Bairati showed that during the follow-up period (average 6.5 years), 179 deaths were recorded in both groups. All-cause mortality, not only cancer-related in the vitamin E group was increased by 38%.

These results, the authors said, concurred with their earlier reports suggesting that high-dose vitamin E could be harmful in head-and-neck cancer patients receiving conventional therapy.

That conclusion is no surprise.

Synthetic alpha-tocopherol vitamin E should not be consumed especially in higher quantities than 50 IU a day.

The term vitamin E describes a family of eight antioxidants (called isoforms)

4 – tocopherols (alpha-, beta-, gamma-, and delta-) and 4 tocotrienols (alpha-, beta-, gamma-, and delta-)

Alpha-tocopherol is the only form of vitamin E that was studied in the SELECT trial and the Bairati study.

In a study of over 10,000 men at the prestigious Johns Hopkins School of Public Health, men who had the highest blood levels of gamma-tocopherol were five times less likely to get prostate cancer (Helzlsouer et al. 2000).

In the SELECT trial, 400IU of synthetic vitamin E was given a group of patients, eventually causing worse prostate cancer.

I have written extensively about the SELECT study, here, here and at the Natural Medicine Journal.

Another Study conceded numerous pathways of most plant chemical antioxidants, far from being pure scavengers of free radicals also induce cancer cell death. A few of these pathways, however, may also lead to tumor cell survival. These authors concluded that although patients should avoid what they call “unnecessary supplementation” during and after radiotherapy, using antioxidants to improve the therapeutic index of radiation is a reasonable and commendable goal.

Studies on Dietary Supplements for Prostate Cancer during Radiation Therapy

Until date, there is one randomized trial looking at the effects of antioxidants supplementation during RT specifically for CaP.

In a group of nearly 140 patients, using green tea extract (500– 750mg BID, standardized to 80% catechins), melatonin (20 mg daily at bedtime), vitamin C (500–1000 mg TID), and vitamin E (200–400IU BID) no adverse events were observed after two years from the supplement group vs. the non-supplement group.

Curcumin during radiation for prostate cancer

There are protective effects of curcumin during radiation therapy. In one study supplementation in one study, the curcumin group experienced much milder urinary symptoms compared with the placebo group. No bowel symptoms or sexual function difference was noticed.

In addition to likely protecting against unwanted urinary symptoms, curcumin use can probably have a radiosensitive effect on cancer cells making them more vulnerable during treatment.

For the scientifically minded reader;  curcumin increases radiation sensitivity was possibly associated with the inhibition of radiation-induced elevation of growth factors, cytokines, cyclins, NF-κB, PKC, TNF-α, and inhibition of cell cycle at the G2 + M phase, increased apoptosis, and some other unknown mechanisms

There is a possibility that curcumin can protect normal tissues against deleterious effects of ionizing radiation as an antioxidant while enhancing the sensitivity of cancer cells to the radiation by mechanisms mentioned above.

A randomized study showed that showed that curcumin improves the antioxidant status of patients with prostate cancer without compromising the therapeutic efficacy of radiotherapy.

The researchers also observed a  significant inverse relationship between the antioxidant levels and urinary symptoms in patients after RT. In other words, curcumin seems to have protected the healthy cells of the urinary system where less urinary problems were noticed after RT.

Dr. Geos Take on the Use of Dietary Supplements During and After Radiation Therapy for Prostate Cancer

Almost every day of my life I am asked questions regarding supplements during RT.

Radiation oncologist vehemently discourage patients from taking antioxidants during radiation treatment in an effort to provide maximal therapeutic benefit with little interference with the treatment. Still, a majority of patients undergoing RT will take one supplement or another while fighting against their disease.

The problem is I’m not sure the patient benefits much from eliminating the careful use of antioxidants during radiation therapy. In fact, the proper combination of antioxidants can protect healthy cells from becoming damaged or malignant and likely enhance, not interfere, with more cancer cell death in conjunction than RT alone.

When counseling prostate cancer patients undergoing RT on supplements my primary goal is to cause less confusion to the patient and their family while providing a sustainable health plan.

Cancer treatment is a frustrating maze and the last thing I want is to induce more angst to the patient by recommending a dietary supplement regimen when the radiation oncologist makes strong recommendations against it.

Such confusion only causes more frustration for the patient and his family.

However, a one hundred million dollar randomized study proving or disproving the effects of antioxidants during RT for prostate cancer will never happen.

I’m confident with the available data and having tracked patients who courageously have gone against physician advice showing that proper combination of antioxidant use does not block the effect of RT but enhances it and likely protect healthy cells from damage.

Detailed Recommendations on AntiOxidant During and After Radiation Therapy for Prostate Cancer.

  • Report to all your doctor’s supplements you are taking.
  • Seek the help of a nutritionally oriented healthcare expert who works with an oncologist.
  • Naturopathic and functional medicine doctors are well-trained in nutrition and non-conventional approaches, but not all are versed in oncology. An organization of doctors who are experts in oncological nutrition is OncANP.
  • Synthetic alpha-tocopherol vitamin E should NOT EVER be used for cancer regardless of treatment for cancer.  There is no reason to use anything other than mixed tocopherol.
  • Vitamins with antioxidant capacity should be used in combination with others. For example, vitamin C, vitamin E, zinc, and alpha lipoic acid work synergistically and prevents too much pro-oxidation.
  • If your radiation oncologist digs her heels into the ground and not allow you take dietary supplements, and you are not working with a nutritionally oriented doctor, take curcumin, about 1000mg to 3000mg a day with food.
  • Print this blog post or forward it to your physician. Maybe they will be open in allowing you to consume the right combination of dietary supplements after reading

 

Good Luck!

 

 

7 Easy, No BS Ways to Staying Healthy on the 4th of July.

[image above from successfully fit]

 

Stay focused on what’s important on this 4th of July; a celebration of your patriotism to the United States ( if you live in the US) and a time to spend with friends and family.

With that in mind, here are the;

7 Realistic, no BS Tips to Staying Well on the 4th of July

1. Take easy on eating grilled animal products, like burgers and chicken. Look, I like these foods too, I am not going to lie. But you have to admit; often there’s nothing special about these foods. Usually, its just a bunch of unseasoned burgers, chicken, and hot dogs doused in ketchup or mustard. Let’s be real; there’s nothing special about that. Plus, the charring on animal products when grilling is a pro-carcinogen.
Tips: Grill portabella mushrooms. They are meaty in texture and taste delicious when seasoned correctly.

HERE’s a good recipe for making portabello mushrooms..

2. Go easy on the booze. I know the 4th of July is a festive moment but over drinking is not worth it. The World Cancer Research Fund makes alcohol as a pro-carcinogen.

I am not saying you need to be a monk at the holiday party. Just be mindful of your alcohol intake and don’t overdo it. Besides, you will start acting silly and embarrassing yourself. ( I see you :))

3. Don’t forget to exercise. I know, I know, its the holidays and you should take it easy and have fun. Guess what; the disease process doesn’t take holidays. You shouldn’t either. Go for a 30-minute workout, especially if you are going to consume less than optimal foods.

The bottom line is that exercising should be part of the holiday fun. If it’s not, do it anyway. It’s good for you, and we sometimes have to do things we don’t like.

4. Drink 8 to 10 glasses of water. It’s hot out there, and you can quickly dehydrate. If you are craving a beer or soda, drink a full glass of water first. Then have the beer if you wish. (Reread # 2) You know if you are drinking enough water if your urine is clear. The darker yellow the urine, the more dehydrated you are. Keep your urine clear.

5. Eat something nourishing before the party. Do not, I repeat, DO NOT wait for the party to eat. That is a recipe for disaster. Don’t go hungry at the party. Make a nice protein smoothie or something and eat before the event. If you go hungry, all bets are off, and you will go crazy with eating nasty burgers with ketchup.

6. Take your dietary supplements. Pills don’t replace good eating and exercise, I get it, but it does counter some of our nutritional deviations. Be disciplined, and down those protective pills.

7. Enjoy the company. Have a good time with people you love is what life is all about. It’s less about the food and drink (although that is a component of it) and more about connecting with amazing people in your life.

 

Three Recent Blog Posts

It’s time to Exercise. No Excuses.

Testosterone and Prostate Cancer; New Study.

Prostate Cancer: How and Why Brocolli helps.

 

CaPLESS EVENTS

The CaPLESS Eats event was a huge success I think. Thank you to all who came. There will be more. As always, we want to help prostate cancer (CaP) thrivers to live their best life by implementing science-based lifestyle practices.

It’s time to Exercise – No More Excuses.

[Image of me training at 4:36 AM. It’s not what I like doing, but what I have to do.]

 

I’ve noticed people making all sorts of excuses not to exercise.

And it’s not because there is no evidence that exercise helps us live longer and better.

The scientific literature is packed with proof that exercise helps prevent and manage depression, cardiovascular disease, cancer and promote longevity.

Despite the plethora of evidence, less than 25% of people exercise.

That’s insane.

Why is that?

After observing the behaviors of thousands of people at my clinic and in my personal life during the last fifteen years or so, I think I have some answers.

Top 5 Reason’s Men Don’t Exercise and What to Do About it

 

  • When “this happens” then I will exercise. I know someone who has purchased every exercise gadget imaginable to exercise at his home. All the fitness books are appropriately lined up on his bookshelf, pull-up bar ready to go, push up bar – everything he needs. He says, “once I get all the equipment and books I need, then I’ll get started.” It’s been three years and he still hasn’t gotten started. There’s no perfect scenario to get going. The time is now. All you need to do is go.

 

  • Fear of looking weak. Men hate vulnerable situations. The discomfort of going to a gym and pushing weight next to a muscle head lifting 400 pounds can be paralyzing. Same with not having the developed stamina to go for a run and deal with the unconformability of gassing out. Fight your vulnerabilities.

             In fact, I’d argue that your best life will only occur with you facing your discomforts instead of shying away from them.

Of course, I’m not saying to jump out of a plane without a parachute. That wouldn’t be smart and extremely painful (or deadly). I am saying the more you challenge yourself and get out of your comfort the better you will live. Resist comparing yourself to others and focus on achieving your personal best.

I consider myself a physically strong guy – I can deadlift 350 pounds, bench press 250 pounds, etc. And still, when I go train at a gym, I’m often one of the weakest there. That’s OK. I am happy with my mental and physical gains.

  • I’m not the physical type. I have noticed that some people are more cerebral than physical. These are your philosophers, computer geeks, scientists, etc. People in this category were likely a bit nerdy in school. They didn’t play many sports growing up and probably felt awkward doing so. One personality type does not have to exclude the other. While some people are apparently more physical and athletic than others, we all need to be both. Find a particular physical activity you enjoy and do it frequently.

 

  • I’m too busy. This is probably the number one excuse. And the biggest BS one of them all. The reality is we all have time for what we value. Once exercising is considered important in one’s life, then doing it is planned for until it becomes a habit. Schedule it in your calendar as if it’s a meeting with the most important person in for your business. Make it so that your life depends on it. Because it does.

 

  • Avoiding physical pain. Some people are trying to prevent pain from soreness, gasping for air on a run or joint pain that sometimes come after working out. Others don’t exercise for fear of getting hurt. Here’s the deal; you can’t live your life in fear. Of course, you can hurt when trying new physical activities. Injuries often occur when one is simply walking down the street too.  However, you can perfect the technique of a particular exercise, don’t do too much too soon and reduce the risk of injury. Also, you are going to experience pain regardless if you opt out of exercising. In fact, the more sedentary you are, the more pain you’ll experience. So, might as well do something that will keep you optimally functional and help you live longer. Make sense?

Lastly, let me say this;

There is no perfect way you should feel before you get going. Frankly, there are many days I’m not up for training. Do it anyway. You don’t always have to be in the best mood to get a workout in. If you are tired from work, life, etc,  go for 10 – 15 minutes and get it in. If the feeling of exhaustion is overbearing, then that’s the only time you rest and not exercise. Know the difference between being tired vs. being exhausted.

If you are starting from zero, the most crucial element of exercising is frequency. In other words, focus less on intensity and duration and more on going out and exercising consistently. Don’t stop.  Just go for a 10-minute brisk walk every day. Or to your gym, you pay or it anyway. Make it a habit of moving your body consistently.

Yes, if you are beyond starting point zero, there’s a prescribed dose on intensity and duration that is important. But even the best exercise regimen only works when you are consistently doing it. The prescriptive dose for exercising is for a different blog post on a different day.

Just do it. – Nike (Best three-word slogan ever)

Testosterone and Prostate Cancer. New Study.

Let’s get right to it.

Study Details on Testosterone and Prostate Cancer

  • A retrospective study observing 147,593 men included 58,617 in men aged 40 to 89 years with low testosterone from 2002 to 2011.
  • 313 aggressive CaPs were diagnosed
  • After adjusting for age, race, hospitalization during the year before cohort entry, geography, BMI, medical comorbidities, repeated testosterone and PSA testing, testosterone treatment was not associated with incident aggressive CaP
  • No association between cumulative testosterone dose or formulation and CaP was observed.

 

My Take on This Recent Study on Testosterone and Prostate Cancer

This PLOS study looked at a large population of close 150,000 men which make provides some validity to the conclusion mentioned despite it being a retrospective study.

A retrospective study looks back to determine risk or protection factors with an outcome that already happened at the start of the study. A retrospective study is the opposite of a prospective study where researchers look forward on a group of subjects before the outcome of interest happens.

Amongst researchers and scientist’ retrospective studies are not held high in its validity because there’s too much room for bias and confounding variables that may influence study conclusion. However, while such studies are not cause-and-effect, retrospective designs provide a vehicle for research using existing and are useful for giving preliminary data and in guiding the development of future prospective studies.

Lastly, one can compare retrospective studies with other better-designed studies to determine its clinical and biological applications.

So, in my opinion, retro studies count in context to the preponderance of other published research.

Let’s look at the overall scientific work done on Testosterone and Prostate Cancer.

Stay with me here. It’s going to get good. ☺

The Relationship between Testosterone and Prostate Cancer (CaP)

Until less than ten years ago it was believed that high endogenous Testosterone (T) led to an increased risk of prostate cancer (CaP) – and treating prostate cancer patients with exogenous T was heretical. In the middle of the 20th century, it was thought that T is the fuel that lit up malignancies in the prostate.

The stark connection that T propelled prostate cancer began in the early 1940’s with Dr. Charles Huggins, a Chicago University urologist and a noble prize winner for his work in demonstrating that prostate cancer growth is dependent on the serum T level. He and his research team observed that dogs with enlarged prostates, or clinically known as benign prostatic hyperplasia (BPH) had their gland shrink after being castrated by surgical removal of the testicles.

Huggins and his research team further noticed that when suspicious, cancerous cells appeared in the prostates of dogs, not only did the prostate shrink after castration but so did suspicious malignant lesions.

The logical sequence for Dr. Huggins is to study the castrating effect in men who had advanced prostate cancer. These men either had their testicles removed or were given estrogen while having the anti-androgenic treatment effects measured by serum acid phosphatase.

Huggins and his coworkers showed that acid phosphatase dropped substantially within days of lowering T in men with prostate cancer, therefore, concluding that high T enhanced prostate cancer growth and reducing T eliminated it. (1)

Finally, there was a viable treatment for prostate cancer in Androgen Deprivation Therapy, it was thought, a disease with almost no cure at the time. From that point forward, lowering T to negligible levels was the standard treatment for prostate malignancies and it is still used today for advanced cases.

Is Testosterone the Fuel for Prostate Cancer (CaP)

In test tubes, testosterone demonstrates an increase in prostate cancer in numerous cancer cell lines but apoptosis (programmed cancer cell death) once androgens are removed. (2) A similar response is found in rat studies: androgens promote tumor progression until androgens are withdrawn – then causing regression of prostate tumor cells. (3)

From test tubes and rat studies, one can easily think, “that’s it, case closed. Testosterone fuels prostate cancer, thus low testosterone in men I best for prostate cancer prevention.”

Human studies analyzed.

A meta-analysis of three prospective studies controlling for testosterone, estradiol, Sex Hormone Binding Globulin (SHBG), age and body mass index (BMI) demonstrated an increase in CaP for men in the highest levels of serum testosterone but no association with DHT or estradiol. (4)

A meta-analysis called the Endogenous Hormones and Prostate Cancer Collaborative Group included 3886 men diagnosed with CaP and 6438 controls. The results demonstrated no direct association between endogenous serum androgens and the development of prostate cancer. (5)

Another, well-designed human clinical trial looked at 3255 men in the placebo arm of the Reduction by Dutasteride of Prostate Cancer Events trial, also known as the REDUCE trial. Prostate biopsies performed at two and four years revealed, no relationship between testosterone or dihydrotestosterone (DHT) levels and prostate cancer risk. (6)
Here’s the kicker; not only is there no causal relationship with high endogenous T and CaP but low T may cause the disease.

One such clinical trial demonstrated a high incidence rate of aggressive, more deadly type of CaP among men with low T defined as >7.6nmo/l (220ng/d). (7)
Similarly, a group of Chinese men, 110 total, showed greater high-grade CaP (higher Gleason score) in men with low T. (8)

Beyond analyzing staging with Gleason grade on biopsy, a high-risk disease has been was associated with low T after prostatectomy.

For example, in 673 men undergoing prostatectomy had their morning T levels taken with surgical pathology outcomes and observed a significant risk of advanced disease that included seminal vesicle invasion in severely hypogonadal men. (9)

What should you do?

First of all, let me be clear here; I don’t have any confirmation bias towards the medical treatment with exogenous testosterone therapy. That’s not what I do as a physician. In men with low T, my goal is to prescribe lifestyle and natural methods to help the body make its own natural hormones.

Secondly, while I am not opposed to pharmaceutical testosterone therapy, once still needs to be properly managed by an experienced health care practitioner if T therapy is right for you. External T therapy by itself is a “Band-Aid” to the problem. It’s a good temporary solution (good long-term solution in some cases), but it is not a cure. The long-lasting remedy usually lies in a lasting lifestyle change.

Causes of low testosterone include chronic high-stress mismanagement, poor sleep habits, lack of physical activity, being overweight, metabolic syndrome…you know, the typical culprits to most health problems.

Lastly, T therapy can safely be prescribed for the right patient, only if necessary, even after a prostate cancer diagnosis.

That’s right. Some men can increase their testosterone levels, either naturally, or with an external application, after prostate cancer diagnosis.

Once we look at much of the research, we can see the PLOS study having some validity despite its retrospective design.

UPCOMING EVENT

Learn what food and meals work best for prostate cancer at the live event CaPLESS Eats.

CaPLESS Eats clears up the confusion on what to eat for prostate cancer.

Closing registration at 11:59, Sunday, June 24th.

3 Blog Posts

14 Rules on Being a Good Father

Part 4: PSA Screening after Prostate Cancer Diagnosis

Prostate Cancer: 10 Reliable Tips to Choose Your Best Treatment

Reference:

1. Huggins C, Hodges CV; Studies on prostatic cancer: I. The effect of castration, of estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate. 1941.J Urol. 2002 Jul; 168(1):9-12.
2. Schwab T., Stewart T., Lehr J., Pienta K., Rhim J., Macoska J. (2000) Phenotypic characterization of immortalized normal and primary tumor-derived human prostate epithelial cell cultures. Prostate 44: 164–171.
3. Ahmad I., Sansom O., Leung H. (2008) Advances in mouse models of prostate cancer. Expert Rev Mol Med 10: e16.
4. Shaneyfelt T., Husein R., Bubley G., Mantzoros C. (2000) Hormonal predictors of prostate cancer: a meta-analysis. J Clin Oncol 18: 847.
5. Roddam A.W., Allen N.E., Appleby P., et al: Endogenous sex hormones and prostate cancer: a collaborative analysis of 18 prospective studies. J Natl Cancer Inst 2008; 100: pp. 170-183
6. Muller R., Gerber L., Moreira D., Andriole G., Castro-Santamaria R., Freedland S. (2012) Serum testosterone and dihydrotestosterone and prostate cancer risk in the placebo arm of the reduction by dutasteride of prostate cancer events trial. Eur Urol 62: 757–764.
7. Lane B., Stephenson A., Magi-Galluzzi C., Lakin M., Klein E. (2008) Low testosterone and risk of biochemical recurrence and poorly differentiated prostate cancer at radical prostatectomy. Urology 72: 1240–1245.
8. Dai B., Qu Y., Kong Y., Ye D., Yao X., Zhang S., et al. (2012) Low pretreatment serum total testosterone is associated with a high incidence of Gleason score 8–10 disease in prostatectomy specimens: data from ethnic Chinese patients with localized prostate cancer. BJU Int 110: E667–E672.
9. Salonia A., Gallina A., Briganti A., Abdollah F., Suardi N., Capitanio U., et al. (2010) Preoperative hypogonadism is not an independent predictor of high-risk disease in patients undergoing radical prostatectomy. Cancer 117: 3953–3962.

Prostate Cancer: Why and How Broccoli Helps

 

Hey, it’s Dr. Geo here!

Have you wondered why cruciferous vegetables are so protective against prostate cancer?

Cruciferous vegetables are those vegetables we call broccoli, cabbage,  bok choy, kale, and Brussel sprouts.

Why are these vegetables particularly so protective against prostate cancer?

One study shows it reduces the risk (of prostate cancer) in those that consume a good amount of cruciferous vegetables by up to 40%.

Another study shows that those who get diagnosed with prostate cancer have a lesser chance of dying from prostate cancer after diagnosis.

The amount to consume is about seven servings of cruciferous vegetables a week.

Why is that? There’s a group of chemicals in cruciferous vegetables called isothiocyanates, and the specific isothiocyanate that is most protective is sulforaphane.  

Another protective compound also in these cruciferous vegetables are indole-3 carbinol.

These are specific chemicals that have anti-cancer properties and stops prostate cancer right in its tracks.

I highly suggest for you to consume seven to nine servings of cruciferous vegetables a week to protect yourself against prostate cancer.

HERE’S THE TRICK though. Cruciferous vegetables need to be steamed or exposed to (some) heat for them to be digested well.

Why is that important?

Well, have you gone to a party or any social function where they have a vegetable platter with the raw broccoli on that platter along with the celery and the white cream dip?

When you eat cruciferous vegetables like broccoli raw is not digested well and that’s why it doesn’t sit well in your digestive system.

So I see so many of my patients eating this broccoli raw and thinking they’re doing something good for themselves.  (They are not)

To best eat broccoli and all cruciferous vegetables they need to be exposed to some heat, not too much, in order to liberate and free up these [anti-cancer] chemicals. And that’s the only way you can get these wonderful phytochemicals in your system to protect you from prostate cancer.

This is Dr. Geo signing off! Until our next video be well 🙂

 

Side note: I find broccoli extracts founds in high-quality supplements to also help in providing the phytochemicals necessary for maximal protection.

UPCOMING EVENT

Learn what food and meals work best for prostate cancer at the live event CaPLESS Eats.

CaPLESS Eats clears up the confusion on what to eat for prostate cancer.

 

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Part 4: PSA Screening after Prostate Cancer Diagnosis

Prostate Cancer: 10 Reliable Tips to Choose Your Best Treatment

 

 

Part Four: PSA Screening After Prostate Cancer Diagnosis

This is part four of a four-part series on the PSA test in an attempt to demystify the most feared blood marker in men.

 

Part one: What is PSA and what it does

Part two: Benign reason’s why PSA goes up

Part three: PSA used for Prostate Cancer Screening 

Part four: PSA after prostate cancer treatment

 

PSA rising after prostate cancer treatment is a bombshell to a man’s psyche.

A 63-year-old patient, one year after prostate cancer surgery, see’s me at the clinic for his recent diagnosis of recurrence PSA. (His PSA begins to rise after being undetectable for one year) He looks at me strangely. I ask him – what’s wrong? He responds, “ I thought I didn’t have ever to worry this S@#T again since I had it taken out. I expect my PSA to be zero forever, no? I’m confused” – he says.

Why is PSA still Measured after Prostate Cancer Treatment?

That freaking blood marker causes everything from anxiety to depression, even after prostate cancer treatment.

Here’s the deal; men who undergo medical treatment of prostate cancer like prostate removal or radiation, unfortunately, believe they are “home-free” after their treatment.

If this were true, why are patients required to return to their urologist every 3 to 6 months for a PSA test after surgery or radiation?

Men after prostatectomy or radiation even more so need to make lifestyle changes to reduce their risk of prostate cancer recurrence.

Here are two reason’s why:

1. Up to 40% of men experience biochemical recurrence (PSA recurrence) after initial treatment. (Freedland et al. 2007)

2. Men treated initially with Radiation Therapy (RT) have a higher chance of getting secondary bladder cancer or rectal cancer (Nieder et al. 2008)

Secondary cancers after initial cancer treatment should not be a surprise after this New York Times article highlighted this critical point.

What’s Considered biochemical recurrence (BCR) or PSA recurrence mean?

After surgical prostate removal (prostatectomy) – PSA recurrence is defined by a PSA of 0.2ng/ml to 0.4ng/ml within 6 to 13 weeks after the surgery.

Ultra-sensitive PSA assays have recently improved detection levels down to 0.01 ng/mL and may lead to better treatment outcomes through the earlier adoption of salvage radiation therapy following RP

After Radiation therapy (RT) for prostate cancer – PSA recurrence is more difficult to determine as PSA initially increase’s (known as PSA bounce) after RT and does not reach its lowest level for up to 18 months. There is no consensus on the definition of treatment failure, but most agree that the lowest PSA value after RT (referred to as the PSA nadir) plus 2 is the cut-off.

For example, let’s say Mr. Doe completed is RT today. His PSA before treatment is, say, 4.5ng/ml. His PSA may continue to go to whatever, say, 6.0 ( I’m making these numbers up) for another year or so (PSA bounce) before it begins to drop steadily. Two years later his name goes down to 2.5 (the nadir). Once his PSA reaches 4.5ng/ml (plus 2.0) that would be considered a PSA recurrence after RT.

Are you with me?

For men who undergo RT as primary treatment for prostate cancer, the most common treatment after PSA recurrence is cryotherapy (freezing the prostate).

Cryotherapy in this patient population can induce close to 100% impotence but not worsen urinary incontinence.

Men on Active Surveillance also are monitored primarily by PSA value and subsequent prostate biopsies. There’s no biochemical or PSA recurrence here since there is no treatment. The typical protocol for men on active surveillance for prostate cancer is biopsy once a year for up to two to three years to assure there has been no cancer progression. However, the physician may not be aware that in the latest research, they’d consider a follow-up biopsy every two years for active surveillance patients, not once a year. Biopsy every other year is indeed a viable approach for men not needing immediate medical treatment for prostate cancer based on research.

A final note on active surveillance for prostate cancer: Up to 33% of patients on active surveillance (AS) eventually fall out of surveillance and undergo definitive treatment after 2–5 years because of initial understaging or disease progression. Understaging means that the initial biopsy may have missed more aggressive prostate cancer with a Gleason 7 or higher.

I suggest a ProActive Surveillance approach in men on active surveillance for prostate cancer with the goal of the disease not to ever progress and reduce the risk of all-cause mortality.

Lastly, the use of PSA after focal therapy for prostate cancer is not well defined. Focal therapy, which includes cryotherapy, focal laser ablation and high-intensity focused ultrasound (HIFU) is a form of treatment for prostate cancer somewhere in between active surveillance and radical therapy. With focal therapy, the goal is to ablate (destroy) only the tumor and maybe about 1cm around it. PSA does not go down to zero after focal therapy since there is still prostate tissue intact and likely inflammation as well from the procedure. However, the PSA value does tend to decrease by 30% to 60% after focal therapy. A rapid increase in PSA after nadir can indicate biochemical recurrence and may require a biopsy.

Though not preferred by the surgeon, radical prostatectomy is an option after focal therapy if prostate cancer recurs.

PSA Doubling Time and other tests to determine Prostate Cancer Prognosis

In general, to determine a risk of aggressivity of prostate cancer, all pretreatment values are essential after PSA recurrence including, pretreatment PSA, tumor stage (T-stage), including Gleason score, surgical margin status, and lymph node status.

After prostate cancer treatment, PSA doubling time (PSADT) likely has the most prognostic value – this is the amount of time it takes for PSA value to double.

Let me give you another example.

Say my PSA today is 2.5ngml and it goes up to 5.0ng/ml in 6 months. The PSADT is six months.

In general, the longer the PSADT after PSA recurrence, the less likelihood of prostate cancer to be deadly.

As of late, genetic testing like Decipher® can help predict the possibility of metastasis from prostate cancer only after a prostatectomy. The Decipher® test only examines the prostate gland after it is removed surgically; thus, this test is not valuable after other type treatments like radiation.

Another element of prognostic importance is the time when PSA recurs after treatment.

For example, I have patients who have PSA recurrence ten to fifteen years after their prostatectomy. These patients will likely not succumb to prostate cancer.

Now, you don’t want to get your PSA test less than every three months to determine PSADT. Three PSA measurements obtained three months apart is considered a reliable foundation for calculation of PSADT.

Generally, the longer the PSADT, the better.

One study of 8,669 patients with prostate cancer treated with surgery (5,918 patients) or radiation (2,751 patients) found that a PSADT of less than three months was significantly associated with prostate cancer-specific mortality

Again, prostate cancer is an opportunity for nutritional and lifestyle changes that can reduce the possibility of succumbing to the disease.

Does Biochemical Recurrence (PSA recurrence) mean I will die from prostate cancer?

Not necessarily.

All-in-all the odds of dying from prostate cancer, even after PSA recurrence are better than almost any other cancer after relapse. Your chances of living longer with quality are particularly in your favor if a favorable lifestyle is adopted which reduces the risk of prostate and overall mortality.

Average time from PSA recurrence to prostate cancer death is 16 years (Freeland et al. 2007), if one’s fate is indeed from this disease. Most men with PSA recurrence, however, die of other causes than from prostate cancer, i.e., heart disease.

Importantly, PSA increase after prostatectomy may be due to benign, non-cancerous prostate tissue left behind after surgery (Djavan et al., 2005).

Only a small group of men die from biochemical recurrence (PSA recurrence) after prostate cancer. One study looked at over six hundred men for about sixteen years after prostate cancer treatment and noticed a tiny number succumbed to their disease after BCR. Based on the conclusion of this study, the odds of you living after BCR are in your favor.

So, stop sweating the PSA so much. I see men with high anxiety provoked when going for their PSA test.

I am reminded of an old Jewish phrase, “Don’t’ die while you are still alive.”

However, we all need a kick in the behind to do more of the things that help us live our best life. And the PSA test helps with that.

When does Androgen Deprivation Therapy after Prostate Cancer Recurrence?

The term Androgen Deprivation Therapy  (also known as hormone therapy) refers to treatments meant to eliminate testosterone production by surgical removal of the testicles or chemically castrate the patient with drugs such as Leuprolide ( there are many others.)

The negative impact on quality of life in men on ADT can be significant, including hot flashes, bone loss, increased fracture risk, sexual dysfunction, loss of libido, memory loss, increased fat deposition, loss of muscle mass and other metabolic changes (increases in cholesterol and insulin resistance) that may increase risk for heart disease.

Lastly, not everybody with BCR (PSA recurrence) needs treatment. A man with a detectable and low PSA level of 0.05ng/ml after RP may have a persistently detectable PSA without significant change for a long time. Such a patient is unlikely to progress and suffer prostate cancer-related death because as Djavan et al. showed, there can be benign prostate tissue left behind.

Key Takeaway Points on PSA Screening after Prostate Cancer Diagnosis

• Biochemical recurrence (PSA increase) after prostate treatment is more common than people think.
• PSA recurrence is not necessarily a death sentence
• PSA doubling time is valuable to determine prognosis
• Pre-treatment values are also helpful
• Genetic testing only after prostatectomy is useful in determining prognosis
• PSA recurrence is a reminder to stay the course and improve your nutrition and lifestyle so that you can live your best life despite prostate cancer recurrence.

Every prostate cancer recurrence situation is different, and the treatment approach should be individualized.

UPCOMING EVENT

Learn what food and meals work best for prostate cancer at the live event CaPLESS Eats.

CaPLESS Eats clears up the confusion on what to eat for prostate cancer.

My last 4 Blog Posts

Prostate Cancer: 10 Reliable Tips to Choose Your Best Treatment

What’s your doctor’s medical philosophy?

The Anti-Cancer Benefits of Curcumin

Breaking News: USPTSF position on Prostate Cancer Screening

Reference:
Nieder AM, Porter MP, Soloway MS. Radiation therapy for prostate cancer increases subsequent risk of bladder and rectal cancer: a population-based cohort study. J Urol. 2008 Nov;180(5):2005-9;
Djavan B., Milani S., Fong Y. K. (2005). Benign positive margins after radical prostatectomy means a poor prognosis – pro. Urology 65, 218–220.
Freedland S. J., Humphreys E. B., Mangold L. A., Eisenberger M., Dorey F. J., Walsh P. C., Partin A. W. (2005). Risk of prostate cancer-specific mortality following biochemical recurrence after radical prostatectomy. JAMA 294, 433–439.

The Anti-Cancer Benefits of Curcumin

Along with ginger and garlic, curcumin is one of my favorite herbs to prevent and even treat health problems naturally.

This potent herb does not only have potent anti-inflammatory properties, which in at by itself is worth taking, but it also has anti-cancer abilities.

I am not exaggerating.

Now, to be clear, I am not saying just taking curcumin that will cure cancer. It’s not that simple.

But taking ample amounts of this botanical should be part of any anti-cancer arsenal.

That is why when I formulated ImmunoPCTN, it was a no-brainer to add ample amounts of curcumin to the formula.

What is Curcumin

Curcumin is a component in the Indian spice turmeric, and it’s a cousin of ginger – another highly protective herb. Curcumin causes the yellow color in your curry dish. Tumeric is a member of the ginger family (Zingiberaceae). Turmeric’s other two curcuminoids are desmethoxycurcumin and bis-desmethoxycurcumin. Ideally, when consuming curcuminoids, you would want all three health-promoting curcuminoids: curcumin, bisdemethoxycurcumin, and dimethoxy curcumin. I know, it’s getting a little technical, but the bottom line is to get enough of this yellow staining compound from spicing your food and from supplementation.

There are over three hundred research papers suggesting curcumin’s protective effects against prostate cancer and more than to four thousand scientific documents showing its inhibitory results against almost all cancer.

While curcumin can be consumed in food, I recommend have my patients take additional curcumin daily from dietary supplements.

How curcumin protects Prostate cells

Chronic inflammation can cause all kinds of health problems in men from heart disease to certain cancers. Regarding prostate cancer, however, chronic inflammation elevates PSA in the prostate gland, which can build up and eventually leads to tumor formation. A clinical trial examined the effect of curcumin on men and showed a drop in PSA numbers.

Curcumin does not falsely lower PSA. In other words, prostate cancer is not hidden while PSA lowers when taking this herg.

How Curcumin protects against prostate cells

Curcumin protects prostate cells (and breast cells) by slowing down the overproduction of inflammatory chemicals called cytokines.

A particular molecule in the body that promotes cytokine production is Nuclear Kappa Factor –b (NFkB). This ancient yellow spice has shown to inhibit progression of excess prostate cell replication by interrupting the action of NFkB in mice.

Curcumin is an excellent herb to take during radiation therapy for cancer.

That’s right. Curcumin actually helps destroy cancer cells during radiation treatment. This is a big deal because virtually all radiation oncologists would recommend against taking supplements during radiation treatment. This recommendation is based on the flawed theory that anti-oxidant supplements are taken during radiation treatment, it may protect cancer cells from the radiation treatment.

But now we know that curcumin makes cancer cells more radiosensitive to radiation therapy. Indeed, taking curcumin can help cancer cells be more vulnerable to radiation therapy.

Lastly, Curcumin has shown to stop spreading of aberrant prostate cells in the body.

The Takeaway on Curcumin and Prostate cells

Here’s the bottom line: spices of all kinds should be consumed daily with food. The scientific community now realizes that the best pharmacy is indeed in the kitchen. Rosemary, Oregano, garlic, turmeric all have anti-cancer properties.

Smart and judicious use of dietary supplements should be an essential part of any health routine if the interest is in preventing or slowing the development of abnormal prostate and breast cells.

Optimal amounts ranges of curcumin vary from 400mg to 4000mg a day. Science daily has suggested up 8 grams a day (8000mg) is safe. Typically, the more aggressive the health challenge, the more curcumin should be consumed.

I consume about 1000 to 2000 mg curcumin from this formula for maximal protection, reduce soreness from workouts and for prostate health. And you should too.